GNAO1

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

Identifiers

GNAO1; DKFZp686O0962; G-ALPHA-o; GNAO

External IDs

OMIM: 139311 MGI: 95775 HomoloGene: 39203

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • receptor signaling protein activity • GTP binding
Biological Process:	• muscle contraction • signal transduction • G-protein coupled receptor protein signaling pathway • dopamine receptor signaling pathway • nervous system development • axon guidance • locomotory behavior • regulation of heart contraction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020988 (mRNA)
NP_066268 (protein)

NM_010308 (mRNA)
NP_034438 (protein)

Location

Chr 16: 54.78 - 54.95 Mb

Chr 8: 96.7 - 96.86 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, also known as GNAO1, is a human gene.^[1]

[edit] References

^ Entrez Gene: GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O.

[edit] Further reading

Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179–212. PMID 11916537.
Coupry I, Duzic E, Lanier SM (1992). "Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go.". J. Biol. Chem. 267 (14): 9852–7. PMID 1349607.
Denker BM, Neer EJ, Schmidt CJ (1992). "Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions.". J. Biol. Chem. 267 (9): 6272–7. PMID 1556134.
Murtagh JJ, Eddy R, Shows TB, et al. (1991). "Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16.". Mol. Cell. Biol. 11 (2): 1146–55. PMID 1899283.
Yi F, Denker BM, Neer EJ (1991). "Structural and functional studies of cross-linked Go protein subunits.". J. Biol. Chem. 266 (6): 3900–6. PMID 1899868.
Tsukamoto T, Toyama R, Itoh H, et al. (1991). "Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 2974–8. PMID 1901650.
Gabrion J, Brabet P, Nguyen Than Dao B, et al. (1990). "Ultrastructural localization of the GTP-binding protein Go in neurons.". Cell. Signal. 1 (1): 107–23. PMID 2518353.
Lavu S, Clark J, Swarup R, et al. (1988). "Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha.". Biochem. Biophys. Res. Commun. 150 (2): 811–5. PMID 3124840.
Zumbihl R, Breuiller-Fouché M, Carrette J, et al. (1995). "Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium.". Eur. J. Pharmacol. 288 (1): 9–15. PMID 7705473.
Grassie MA, Milligan G (1995). "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.". Biochem. J. 306 ( Pt 2): 525–30. PMID 7887906.
Wu HC, Lin CT (1994). "Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.". Lab. Invest. 71 (2): 175–81. PMID 8078296.
Nitta K, Uchida K, Kawashima A, et al. (1994). "Identification of GTP-binding proteins in human glomeruli.". Nippon Jinzo Gakkai shi 36 (1): 9–12. PMID 8107314.
Georgoussi Z, Carr C, Milligan G (1993). "Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go.". Mol. Pharmacol. 44 (1): 62–9. PMID 8393523.
Laugwitz KL, Allgeier A, Offermanns S, et al. (1996). "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116–20. PMID 8552586.
Kawano N, Ito T, Kitamura H, et al. (1997). "Immunoexpression of the alpha subunit of a guanine nucleotide-binding protein (Go) in pulmonary neuroendocrine cells and neoplasms.". Pathol. Int. 46 (6): 393–8. PMID 8869990.
De Vries L, Elenko E, Hubler L, et al. (1997). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203–8. PMID 8986788.
Valenzuela D, Han X, Mende U, et al. (1997). "G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart.". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1727–32. PMID 9050846.
Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.". J. Biol. Chem. 272 (13): 8679–85. PMID 9079700.
Natochin M, Lipkin VM, Artemyev NO (1997). "Interaction of human retinal RGS with G-protein alpha-subunits.". FEBS Lett. 411 (2-3): 179–82. PMID 9271201.
Busconi L, Denker BM (1998). "Analysis of the N-terminal binding domain of Go alpha.". Biochem. J. 328 ( Pt 1): 23–31. PMID 9359829.