GNAL

From Wikipedia, the free encyclopedia

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

Identifiers

External IDs

OMIM: 139312 MGI: 95774 HomoloGene: 68222

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • signal transducer activity • GTP binding
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002071 (mRNA)
NP_002062 (protein)

NM_010307 (mRNA)
NP_034437 (protein)

Location

Chr 18: 11.68 - 11.87 Mb

Chr 18: 67.21 - 67.35 Mb

Pubmed search

[1]

[2]

Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type, also known as GNAL, is a human gene.^[1]

[edit] References

^ Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type.

[edit] Further reading

Wilkie TM, Gilbert DJ, Olsen AS, et al. (1993). "Evolution of the mammalian G protein alpha subunit multigene family.". Nat. Genet. 1 (2): 85-91. doi:10.1038/ng0592-85. PMID 1302014.
Zigman JM, Westermark GT, LaMendola J, et al. (1994). "Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.". Endocrinology 133 (6): 2508-14. PMID 8243272.
Astesano A, Regnauld K, Ferrand N, et al. (1999). "Cellular and subcellular expression of Golf/Gs and Gq/G11 alpha-subunits in rat pancreatic endocrine cells.". J. Histochem. Cytochem. 47 (3): 289-302. PMID 10026232.
Vuoristo JT, Berrettini WH, Overhauser J, et al. (2001). "Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia.". Mol. Psychiatry 5 (5): 495-501. PMID 11032382.
Zill P, Engel R, Baghai TC, et al. (2002). "Analysis of polymorphisms in the olfactory G-protein Golf in major depression.". Psychiatr. Genet. 12 (1): 17-22. PMID 11901355.
Régnauld K, Nguyen QD, Vakaet L, et al. (2002). "G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells.". Oncogene 21 (25): 4020-31. doi:10.1038/sj.onc.1205498. PMID 12037684.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zill P, Malitas PN, Bondy B, et al. (2004). "Analysis of polymorphisms in the alpha-subunit of the olfactory G-protein Golf in lithium-treated bipolar patients.". Psychiatr. Genet. 13 (2): 65-9. doi:10.1097/01.ypg.0000057881.80011.45. PMID 12782961.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Corradi JP, Ravyn V, Robbins AK, et al. (2005). "Alternative transcripts and evidence of imprinting of GNAL on 18p11.2.". Mol. Psychiatry 10 (11): 1017-25. doi:10.1038/sj.mp.4001713. PMID 16044173.
Ravyn V, Bostwick JR (2006). "Functional coupling of the Galpha(olf) variant XLGalpha(olf) with the human adenosine A2A receptor.". J. Recept. Signal Transduct. Res. 26 (4): 241-58. doi:10.1080/10799890600710592. PMID 16818375.