GMDS (gene)

From Wikipedia, the free encyclopedia

GDP-mannose 4,6-dehydratase

PDB rendering based on 1t2a.

Available structures: 1t2a

Identifiers

Symbol(s)

GMDS; GMD

External IDs

OMIM: 602884 MGI: 1891112 HomoloGene: 75968

Gene ontology
Molecular Function:	• GDP-mannose 4,6-dehydratase activity • lyase activity • coenzyme binding
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• carbohydrate metabolic process • leukocyte adhesion • GDP-mannose metabolic process • 'de novo' GDP-L-fucose biosynthetic process • cellular metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001500 (mRNA)
NP_001491 (protein)

NM_146041 (mRNA)
NP_666153 (protein)

Location

Chr 6: 1.57 - 2.19 Mb

Chr 13: 31.83 - 32.35 Mb

Pubmed search

[1]

[2]

GDP-mannose 4,6-dehydratase, also known as GMDS, is a human gene.^[1]

[edit] References

^ Entrez Gene: GMDS GDP-mannose 4,6-dehydratase.

[edit] Further reading

Sullivan FX, Kumar R, Kriz R, et al. (1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro.". J. Biol. Chem. 273 (14): 8193-202. PMID 9525924.
Ohyama C, Smith PL, Angata K, et al. (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells.". J. Biol. Chem. 273 (23): 14582-7. PMID 9603974.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.". J. Biol. Chem. 277 (5): 3168-75. doi:10.1074/jbc.M107927200. PMID 11698403.
Eshel R, Besser M, Zanin A, et al. (2002). "The FX enzyme is a functional component of lymphocyte activation.". Cell. Immunol. 213 (2): 141-8. doi:10.1006/cimm.2001.1872. PMID 11831876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.