Glyoxylate reductase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a glyoxylate reductase (NADP+) (EC 1.1.1.79) is an enzyme that catalyzes the chemical reaction

glycolate + NADP⁺ $\rightleftharpoons$ glyoxylate + NADPH + H⁺

Thus, the two substrates of this enzyme are glycolate and NADP⁺, whereas its 3 products are glyoxylate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NADP+ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP+). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2GCG, 2H1S, and 2Q50.

[edit] References

IUBMB entry for 1.1.1.79
BRENDA references for 1.1.1.79 (Recommended.)
PubMed references for 1.1.1.79
PubMed Central references for 1.1.1.79
Google Scholar references for 1.1.1.79
Cartwright LN and Hullin RP (1966). "Purification and properties of two glyoxylate reductases from a species of Pseudomonas". Biochem. J. 101: 781–791.
Kleczkowski LA, Randall DD, Blevins DG (1986). "Purification and characterization of a novel NADPH(NADH)-dependent glyoxylate reductase from spinach leaves. Comparison of immunological properties of leaf glyoxylate reductase and hydroxypyruvate reductase". Biochem. J. 239: 653–9. PMID 3548703.