Glycoside hydrolase family 1

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Glycosyl hydrolase family 1
Identifiers
Symbol Glyco_hydro_1
Pfam PF00232
InterPro IPR001360
PROSITE PDOC00495
SCOP 1cbg
OPM family 125
OPM protein 1vff
Available PDB structures:

4pbgB:1-467 3pbgB:1-467 1pbgA:1-467 2pbgA:1-467 1cbg :26-410 1v02D:72-551 1v03A:72-551 1v08B:74-558 1e1fA:74-558 1hxjB:74-558 1e4nB:74-558 1e55B:74-558 1e4lA:74-558 1e1eA:74-558 1e56B:74-558 1h49A:74-558 1e73M:21-222 1e72M:21-222 1e4mM:21-222 1e6sM:21-222 1e6qM:21-222 1e70M:21-222 1e6xM:21-222 1e71M:21-222 1mquA:3-435 1uz1A:2-444 1oinA:2-444 1oimB:2-444 1od0A:2-444 1oifB:2-444 1w3jB:2-444 1ug6A:1-431 1np2A:1-431 1gonB:14-476 1gnxB:14-476 1bggC:2-444 1bgaA:2-444 1tr1C:2-444 1e4iA:2-444 1uyqA:2-444 1qoxL:2-448 1wcgA:1-464 1uwsA:308-471 1uwrA:308-471 1uwqB:308-471 1uwiA:308-471 1uwuA:308-471 1gowA:308-471 1uwtA:308-471 1qvbA:307-470 1vffA:1-408

Glycoside hydrolase family 1 is a family of glycoside hydrolases.

O-Glycosyl hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families[1][2][3]. This classification is available on the CAZy(CArbohydrate-Active EnZymes) web site[4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'.

Glycoside hydrolase family 1 CAZY GH_1 comprises enzymes with a number of known activities; beta-glucosidase (EC 3.2.1.21); beta-galactosidase (EC 3.2.1.23); 6-phospho-beta-galactosidase (EC 3.2.1.85); 6-phospho-beta-glucosidase (EC 3.2.1.86); lactase-phlorizin hydrolase (EC 3.2.1.62), lactase (EC 3.2.1.108); beta-mannosidase (EC 3.2.1.25); myrosinase (EC 3.2.1.147).

Contents

[edit] Subfamilies

[edit] Human proteins containing this domain

GBA3; KL; KLB; LCT; LCTL;

[edit] See also

GH1 in CAZypedia

[edit] References

  1. ^ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090-7094. PMID 7624375. 
  2. ^ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853-859. PMID 8535779. 
  3. ^ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
  4. ^ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
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