Glycoprotein IX

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Glycoprotein IX (platelet)
Identifiers
Symbol(s) GP9; CD42a; GPIX
External IDs OMIM: 173515 MGI: 1860137 HomoloGene: 144
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2815 54368
Ensembl ENSG00000169704 ENSMUSG00000030054
Uniprot P14770 n/a
Refseq NM_000174 (mRNA)
NP_000165 (protein)		 NM_018762 (mRNA)
NP_061232 (protein)
Location Chr 3: 130.26 - 130.26 Mb Chr 6: 87.74 - 87.75 Mb
Pubmed search [1] [2]

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.[1]

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM][1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: GP9 glycoprotein IX (platelet).

[edit] Further reading

  • Kunishima S, Kamiya T, Saito H (2003). "Genetic abnormalities of Bernard-Soulier syndrome.". Int. J. Hematol. 76 (4): 319-27. PMID 12463594. 
  • Hickey MJ, Deaven LL, Roth GJ (1991). "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3.". FEBS Lett. 274 (1-2): 189-92. PMID 2253772. 
  • Du X, Beutler L, Ruan C, et al. (1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane.". Blood 69 (5): 1524-7. PMID 2436691. 
  • Andrews RK, Booth WJ, Gorman JJ, et al. (1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex.". Biochemistry 28 (21): 8317-26. PMID 2557900. 
  • Hickey MJ, Williams SA, Roth GJ (1989). "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures.". Proc. Natl. Acad. Sci. U.S.A. 86 (17): 6773-7. PMID 2771955. 
  • Roth GJ, Ozols J, Nugent DJ, Williams SA (1988). "Isolation and characterization of human platelet glycoprotein IX.". Biochem. Biophys. Res. Commun. 156 (2): 931-9. PMID 3056407. 
  • Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells.". J. Biol. Chem. 270 (24): 14693-9. PMID 7782333. 
  • Clemetson JM, Kyrle PA, Brenner B, Clemetson KJ (1994). "Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX.". Blood 84 (4): 1124-31. PMID 8049428. 
  • Hickey MJ, Roth GJ (1993). "Characterization of the gene encoding human platelet glycoprotein IX.". J. Biol. Chem. 268 (5): 3438-43. PMID 8429020. 
  • Wright SD, Michaelides K, Johnson DJ, et al. (1993). "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome.". Blood 81 (9): 2339-47. PMID 8481514. 
  • Berger G, Massé JM, Cramer EM (1996). "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V.". Blood 87 (4): 1385-95. PMID 8608228. 
  • Hollmann C, Haag F, Schlott M, et al. (1996). "Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products.". Mol. Immunol. 33 (9): 807-17. PMID 8811076. 
  • Noris P, Simsek S, Stibbe J, von dem Borne AE (1997). "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome.". Br. J. Haematol. 97 (2): 312-20. PMID 9163595. 
  • Hayashi T, Suzuki K, Yahagi A, et al. (1997). "Corrected DNA sequence of the platelet glycoprotein IX gene.". Thromb. Haemost. 77 (5): 1034-5. PMID 9184424. 
  • Bradford HN, Dela Cadena RA, Kunapuli SP, et al. (1997). "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex.". Blood 90 (4): 1508-15. PMID 9269768. 
  • Suzuki K, Hayashi T, Yahagi A, et al. (1998). "Novel point mutation in the leucine-rich motif of the platelet glycoprotein IX associated with Bernard-Soulier syndrome.". Br. J. Haematol. 99 (4): 794-800. PMID 9432024. 
  • Noris P, Arbustini E, Spedini P, et al. (1999). "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV.". Br. J. Haematol. 103 (4): 1004-13. PMID 9886312. 
  • Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states.". Eur. J. Biochem. 263 (1): 104-11. PMID 10429193. 
  • Kunishima S, Tomiyama Y, Honda S, et al. (2000). "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome.". Br. J. Haematol. 107 (3): 539-45. PMID 10583255. 
  • Rivera CE, Villagra J, Riordan M, et al. (2001). "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome.". Br. J. Haematol. 112 (1): 105-8. PMID 11167791. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350