Glycoprotein IIb/IIIa

From Wikipedia, the free encyclopedia

Identifiers
Symbol ITGA2B
Alt. Symbols GP2B
Entrez 3674
HUGO 6138
OMIM 607759
RefSeq NM_000419
UniProt P08514
Other data
Locus Chr. 17 q21.32
Identifiers
Symbol ITGB3
Alt. Symbols GP3A
Entrez 3690
HUGO 6156
OMIM 173470
RefSeq NM_000212
UniProt P05106
Other data
Locus Chr. 17 q21.32

In medicine, glycoprotein IIb/IIIa, also gpIIb/IIIa, is an integrin found on platelets. Calcium-dependent association of gpIIb and gpIIIa is required for normal platelet aggregation and endothelial adherence.[1][2]

Contents

[edit] Pathology

Defects in glycoprotein IIb/IIIa causes Glanzmann's thrombasthenia.[3]

[edit] Medicine

Glycoprotein IIb/IIIa inhibitors can be used to prevent blood clots in an effort to decrease the risk of heart attack or stroke.

[edit] See also

[edit] References

  1. ^ Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4): 346–60. PMID 7535429. 
  2. ^ Shattil SJ (1999). "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thromb. Haemost. 82 (2): 318–25. PMID 10605720. 
  3. ^ Bellucci S, Caen J (2002). "Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment". Blood Rev. 16 (3): 193–202. doi:10.1016/S0268-960X(02)00030-9. PMID 12163005. 

[edit] External links

 This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.
v • d • e
Membrane proteins: cell adhesion molecules
IgSF
Cadherins
Selectins
Integrins
LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs)
Other