Glycolipid transfer protein

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Glycolipid transfer protein (GLTP)
Identifiers
Symbol GLTP
Pfam PF08718
InterPro IPR014830
OPM family 92
OPM protein 1swx
Available PDB structures:

1swxA:6-207 2evtA:6-207 1sx6A:6-207 1wbeA:6-207 2bv7A:6-207 1tfjA:6-207

Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes. [1][2].

This protein transport primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.

[edit] Human proteins containing this domain

GLTP; PLEKHA8; PLEKHA9;

[edit] References

  1. ^ Brown RE, Lin X, Rao CS, Pike HM, Molotkovsky JG (2004). "Glycolipid transfer protein mediated transfer of glycosphingol ipids between membranes: a model for action based on kinetic and thermodynamic analyses". Biochemistry 43 (43): -. doi:10.1021/bi0492197. PMID 15504043. 
  2. ^ Nymalm Y, Airenne TT, Kidron H, Salminen TA, Nylund M, West G, Mattjus P (2006). "Structural evidence for adaptive ligand binding of glycolipid transfer protein". J. Mol. Biol. 355 (2): -. PMID 16309699. 

[edit] External links

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