Glycolipid 3-alpha-mannosyltransferase

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In enzymology, a glycolipid 3-alpha-mannosyltransferase (EC 2.4.1.132) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a lipid-linked oligosaccharide, being attached by an alpha-1,3-D-mannosyl-D-mannose bond.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase. Other names in common use include mannosyltransferase II, guanosine diphosphomannose-oligosaccharide-lipid II, mannosyltransferase, and GDP-mannose-oligosaccharide-lipid mannosyltransferase II. This enzyme participates in the biosynthesis of n-glycan and glycan structures.

[edit] References

• IUBMB entry for 2.4.1.132
• BRENDA references for 2.4.1.132 (Recommended.)
• PubMed references for 2.4.1.132
• PubMed Central references for 2.4.1.132
• Google Scholar references for 2.4.1.132
• Jensen JW, Schutzbach JS (1981). "The biosynthesis of oligosaccharide-lipids. Partial purification and characterization of mannosyltransferase II". J. Biol. Chem. 256: 12899–904. PMID 7309740. 

[edit] External links

The CAS registry number for this enzyme class is 81181-76-2.

• IUBMB entry for 2.4.1.132

• KEGG entry for 2.4.1.132

• BRENDA entry for 2.4.1.132

• NiceZyme view of 2.4.1.132

• EC2PDB: PDB structures for 2.4.1.132

• PRIAM entry for 2.4.1.132

• PUMA2 entry for 2.4.1.132

• IntEnz: Integrated Enzyme entry for 2.4.1.132

• MetaCyc entry for 2.4.1.132

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004378: glycolipid 3-alpha-mannosyltransferase

• AMIGO entry for GO code 0004378: glycolipid 3-alpha-mannosyltransferase