Glycolipid 2-alpha-mannosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a glycolipid 2-alpha-mannosyltransferase (EC 2.4.1.131) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to lipid-linked oligosaccharide, being attached by an alpha-1,2-D-mannosyl-D-mannose bond.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-oligosaccharide-lipid, mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, and oligosaccharide-lipid mannosyltransferase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1S4N, 1S4O, and 1S4P.

[edit] References

• IUBMB entry for 2.4.1.131
• BRENDA references for 2.4.1.131 (Recommended.)
• PubMed references for 2.4.1.131
• PubMed Central references for 2.4.1.131
• Google Scholar references for 2.4.1.131
• Schutzbach JS, Springfield JD, Jensen JW (1980). "The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage". J. Biol. Chem. 255: 4170–5. PMID 6154707. 

[edit] External links

The CAS registry number for this enzyme class is 74506-43-7.

• IUBMB entry for 2.4.1.131

• KEGG entry for 2.4.1.131

• BRENDA entry for 2.4.1.131

• NiceZyme view of 2.4.1.131

• EC2PDB: PDB structures for 2.4.1.131

• PRIAM entry for 2.4.1.131

• PUMA2 entry for 2.4.1.131

• IntEnz: Integrated Enzyme entry for 2.4.1.131

• MetaCyc entry for 2.4.1.131

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004377: glycolipid 2-alpha-mannosyltransferase

• AMIGO entry for GO code 0004377: glycolipid 2-alpha-mannosyltransferase