Glycolaldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a glycolaldehyde dehydrogenase (EC 1.2.1.21) is an enzyme that catalyzes the chemical reaction

glycolaldehyde + NAD⁺ + H₂O glycolate + NADH + 2 H⁺

The 3 substrates of this enzyme are glycolaldehyde, NAD⁺, and H₂O, whereas its 3 products are glycolate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HG2, 2ILU, and 2IMP.

[edit] References

• IUBMB entry for 1.2.1.21
• BRENDA references for 1.2.1.21 (Recommended.)
• PubMed references for 1.2.1.21
• PubMed Central references for 1.2.1.21
• Google Scholar references for 1.2.1.21
• Davies DD (1960). "The purification and properties of glycolaldehyde dehydrogenase". J. Exp. Bot. 11: 289–295. doi:10.1093/jxb/11.3.289. 

[edit] External links

The CAS registry number for this enzyme class is 37250-89-8.

• IUBMB entry for 1.2.1.21

• KEGG entry for 1.2.1.21

• BRENDA entry for 1.2.1.21

• NiceZyme view of 1.2.1.21

• EC2PDB: PDB structures for 1.2.1.21

• PRIAM entry for 1.2.1.21

• PUMA2 entry for 1.2.1.21

• IntEnz: Integrated Enzyme entry for 1.2.1.21

• MetaCyc entry for 1.2.1.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050569: glycolaldehyde dehydrogenase

• AMIGO entry for GO code 0050569: glycolaldehyde dehydrogenase