Glycogenin glucosyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a glycogenin glucosyltransferase (EC 2.4.1.186) is an enzyme that catalyzes the chemical reaction

UDP-alpha-D-glucose + glycogenin $\rightleftharpoons$ UDP + alpha-D-glucosylglycogenin

Thus, the two substrates of this enzyme are UDP-alpha-D-glucose and glycogenin, whereas its two products are UDP and alpha-D-glucosylglycogenin.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase. Other names in common use include glycogenin, priming glucosyltransferase, and UDP-glucose:glycogenin glucosyltransferase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1LL0, 1LL2, 1LL3, 1ZCT, 1ZCU, 1ZCV, 1ZCY, 1ZDF, and 1ZDG.

[edit] References

IUBMB entry for 2.4.1.186
BRENDA references for 2.4.1.186 (Recommended.)
PubMed references for 2.4.1.186
PubMed Central references for 2.4.1.186
Google Scholar references for 2.4.1.186
Krisman CR, Barengo R (1975). "A precursor of glycogen biosynthesis: alpha-1,4-glucan-protein". Eur. J. Biochem. 52: 117–23. doi:10.1111/j.1432-1033.1975.tb03979.x. PMID 809265.
Pitcher J, Smythe C, Campbell DG, Cohen P (1987). "Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin". Eur. J. Biochem. 169: 497–502. doi:10.1111/j.1432-1033.1987.tb13637.x. PMID 3121316.
Pitcher J, Smythe C, Cohen P (1988). "Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle". Eur. J. Biochem. 176: 391–5. doi:10.1111/j.1432-1033.1988.tb14294.x. PMID 2970965.
Berman, M.C. and Opie, L.A. (Eds.), Membranes and Muscle, ICSU Press/IRL Press, Oxford, 1985, p. 65-84.
Rodriguez IR, Whelan WJ (1985). "A novel glycosyl-amino acid linkage: rabbit-muscle glycogen is covalently linked to a protein via tyrosine". Biochem. Biophys. Res. Commun. 132: 829–36. doi:10.1016/0006-291X(85)91206-9. PMID 4062948.
Lomako J, Lomako WM, Whelan WJ (1988). "A self-glucosylating protein is the primer for rabbit muscle glycogen biosynthesis". FASEB. J. 2: 3097–103. PMID 2973423.
Alonso MD, Lomako J, Lomako WM, Whelan WJ (1995). "Catalytic activities of glycogenin additional to autocatalytic self-glucosylation". J. Biol. Chem. 270: 15315–9. doi:10.1074/jbc.270.25.15315. PMID 7797519.
Alonso MD, Lomako J, Lomako WM, Whelan WJ (1995). "A new look at the biogenesis of glycogen". FASEB. J. 9: 1126–37. PMID 7672505.
Mu J, Roach PJ (1998). "Characterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism". J. Biol. Chem. 273: 34850–6. doi:10.1074/jbc.273.52.34850. PMID 9857012.
Gibbons BJ, Roach PJ, Hurley TD (2002). "Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin". J. Mol. Biol. 319: 463–77. doi:10.1016/S0022-2836(02)00305-4. PMID 12051921.