Glycine reductase

From Wikipedia, the free encyclopedia

In enzymology, a glycine reductase (EC 1.21.4.2) is an enzyme that catalyzes the chemical reaction

acetyl phosphate + NH₃ + thioredoxin disulfide + H₂O glycine + phosphate + thioredoxin

The 4 substrates of this enzyme are acetyl phosphate, NH₃, thioredoxin disulfide, and H₂O, whereas its 3 products are glycine, phosphate, and thioredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with a disulfide as acceptor. The systematic name of this enzyme class is acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming).

[edit] References

• IUBMB entry for 1.21.4.2
• BRENDA references for 1.21.4.2 (Recommended.)
• PubMed references for 1.21.4.2
• PubMed Central references for 1.21.4.2
• Google Scholar references for 1.21.4.2
• Andreesen JR (1999). "Substrate-specific selenoprotein B of glycine reductase from Eubacterium acidaminophilum. Biochemical and molecular analysis". Eur. J. Biochem. 260: 38–49. doi:10.1046/j.1432-1327.1999.00107.x. PMID 10091582. 
• Bednarski B, Andreesen JR, Pich A (2001). "In vitro processing of the proproteins GrdE of protein B of glycine reductase and PrdA of D-proline reductase from Clostridium sticklandii: formation of a pyruvoyl group from a cysteine residue". Eur. J. Biochem. 268: 3538–44. doi:10.1046/j.1432-1327.2001.02257.x. PMID 11422384. 

[edit] External links

• IUBMB entry for 1.21.4.2

• KEGG entry for 1.21.4.2

• BRENDA entry for 1.21.4.2

• NiceZyme view of 1.21.4.2

• EC2PDB: PDB structures for 1.21.4.2

• PRIAM entry for 1.21.4.2

• PUMA2 entry for 1.21.4.2

• IntEnz: Integrated Enzyme entry for 1.21.4.2

• MetaCyc entry for 1.21.4.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030699: glycine reductase

• AMIGO entry for GO code 0030699: glycine reductase