Glycine formimidoyltransferase

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In enzymology, a glycine formimidoyltransferase (EC 2.1.2.4) is an enzyme that catalyzes the chemical reaction

5-formimidoyltetrahydrofolate + glycine $\rightleftharpoons$ tetrahydrofolate + N-formimidoylglycine

Thus, the two substrates of this enzyme are 5-formimidoyltetrahydrofolate and glycine, whereas its two products are tetrahydrofolate and N-formimidoylglycine.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase. Other names in common use include formiminoglycine formiminotransferase, FIG formiminotransferase, and glycine formiminotransferase. This enzyme participates in purine metabolism and one carbon pool by folate.

[edit] References

IUBMB entry for 2.1.2.4
BRENDA references for 2.1.2.4 (Recommended.)
PubMed references for 2.1.2.4
PubMed Central references for 2.1.2.4
Google Scholar references for 2.1.2.4
Rabinowitz JC and Pricer WE (1956). "Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid". J. Am. Chem. Soc. 78: 5702–5704. doi:10.1021/ja01602a073.
Rabinowitz JC and Pricer WE (1957). "Formation, isolation and properties of 5-formiminotetrahydrofolic acid". Fed. Proc. 16: 236.
Sagers RD, Beck JV, Gruber W and Gunsalus IC (1956). "A tetrahydrofolic acid linked formimino transfer enzyme". J. Am. Chem. Soc. 78: 694–695.