Glycine dehydrogenase (decarboxylating)

From Wikipedia, the free encyclopedia

In enzymology, a glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) is an enzyme that catalyzes the chemical reaction

glycine + H-protein-lipoyllysine H-protein-S-aminomethyldihydrolipoyllysine + CO₂

Thus, the two substrates of this enzyme are glycine and H-protein-lipoyllysine, whereas its two products are H-protein-S-aminomethyldihydrolipoyllysine and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with a disulfide as acceptor. The systematic name of this enzyme class is glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating). Other names in common use include P-protein, glycine decarboxylase, glycine-cleavage complex, glycine:lipoylprotein oxidoreductase (decarboxylating and, acceptor-aminomethylating), and protein P1. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1HPC, 1HTP, 1WYT, 1WYU, and 1WYV.

[edit] References

• IUBMB entry for 1.4.4.2
• BRENDA references for 1.4.4.2 (Recommended.)
• PubMed references for 1.4.4.2
• PubMed Central references for 1.4.4.2
• Google Scholar references for 1.4.4.2
• Hiraga K, Kikuchi G (1980). "The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein". J. Biol. Chem. 255: 11671–6. PMID 7440563. 
• Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions". Annu. Rev. Biochem. 69: 961–1004. doi:10.1146/annurev.biochem.69.1.961. PMID 10966480. 
• Broadwater JA, Haas JA, Fox BG, Booker SJ (2005). "Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase". Protein. Expr. Purif. 39: 269–82. PMID 15642479. 

[edit] External links

The CAS registry number for this enzyme class is 37259-67-9.

• IUBMB entry for 1.4.4.2

• KEGG entry for 1.4.4.2

• BRENDA entry for 1.4.4.2

• NiceZyme view of 1.4.4.2

• EC2PDB: PDB structures for 1.4.4.2

• PRIAM entry for 1.4.4.2

• PUMA2 entry for 1.4.4.2

• IntEnz: Integrated Enzyme entry for 1.4.4.2

• MetaCyc entry for 1.4.4.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004375: glycine dehydrogenase (decarboxylating)

• AMIGO entry for GO code 0004375: glycine dehydrogenase (decarboxylating)