Glyceryl-ether monooxygenase

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In enzymology, a glyceryl-ether monooxygenase (EC 1.14.16.5) is an enzyme that catalyzes the chemical reaction

1-alkyl-sn-glycerol + tetrahydrobiopterin + O₂ $\rightleftharpoons$ 1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H₂O

The 3 substrates of this enzyme are 1-alkyl-sn-glycerol, tetrahydrobiopterin, and O₂, whereas its 3 products are 1-hydroxyalkyl-sn-glycerol, dihydrobiopterin, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced pteridine as one donor, and incorporation of one ato of oxygen into the other donor. The systematic name of this enzyme class is 1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase. Other names in common use include glyceryl-ether cleaving enzyme, alkylglycerol monooxygenase, glyceryl ether oxygenase, glyceryl etherase, and O-alkylglycerol monooxygenase. It has 2 cofactors: glutathione, and Phospholipid.

[edit] References

IUBMB entry for 1.14.16.5
BRENDA references for 1.14.16.5 (Recommended.)
PubMed references for 1.14.16.5
PubMed Central references for 1.14.16.5
Google Scholar references for 1.14.16.5
Ishibashi T, Imai Y (1983). "Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes". Eur. J. Biochem. 132: 23–7. doi:10.1111/j.1432-1033.1983.tb07320.x. PMID 6840084.
Pfleger RC, Piantadosi C, Snyder F (1967). "The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species". Biochim. Biophys. Acta. 144: 633–48. PMID 4383918.
Snyder F, Malone B, Piantadosi C (1973). "Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity". Biochim. Biophys. Acta. 316: 259–65. PMID 4355017.
Soodsma JF, Piantadosi C, Snyder F (1972). "Partial characterization of the alkylglycerol cleavage enzyme system of rat liver". J. Biol. Chem. 247: 3923–9. PMID 4402391.
Tietz A, Lindberg M and Kennedy EP (1964). "A new pteridine-requiring enzyme system for the oxidation of glyceryl ethers". J. Biol. Chem. 239: 4081–4090.