Glycerophosphoinositol inositolphosphodiesterase

From Wikipedia, the free encyclopedia

In enzymology, a glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction

1-(sn-glycero-3-phospho)-1D-myo-inositol + H₂O glycerol + 1D-myo-inositol 1-phosphate

Thus, the two substrates of this enzyme are 1-(sn-glycero-3-phospho)-1D-myo-inositol and H₂O, whereas its two products are glycerol and 1D-myo-inositol 1-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase. Other names in common use include 1,2-cyclic-inositol-phosphate phosphodiesterase, D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase, D-inositol 1,2-cyclic phosphate 2-phosphohydrolase, D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase, 1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase, and inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase.

[edit] References

• IUBMB entry for 3.1.4.43
• BRENDA references for 3.1.4.43 (Recommended.)
• PubMed references for 3.1.4.43
• PubMed Central references for 3.1.4.43
• Google Scholar references for 3.1.4.43
• Dawson RM, Hemington N (1977). "A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol". Biochem. J. 162: 241–5. PMID 192216. 
• Dawson RM, Clarke N (1972). "D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase". Biochem. J. 127: 113–8. PMID 4342209. 
• Dawson RM, Clarke NG (1973). "A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney". Biochem. J. 134: 59–67. PMID 4353088. 
• Ross TS, Majerus PW (1991). "Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate". J. Biol. Chem. 266: 851–6. PMID 1845995. 

[edit] External links

The CAS registry number for this enzyme class is 9076-91-9.

• IUBMB entry for 3.1.4.43

• KEGG entry for 3.1.4.43

• BRENDA entry for 3.1.4.43

• NiceZyme view of 3.1.4.43

• EC2PDB: PDB structures for 3.1.4.43

• PRIAM entry for 3.1.4.43

• PUMA2 entry for 3.1.4.43

• IntEnz: Integrated Enzyme entry for 3.1.4.43

• MetaCyc entry for 3.1.4.43

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047394: glycerophosphoinositol inositolphosphodiesterase

• AMIGO entry for GO code 0047394: glycerophosphoinositol inositolphosphodiesterase