Glycerophosphocholine phosphodiesterase

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In enzymology, a glycerophosphocholine phosphodiesterase (EC 3.1.4.2) is an enzyme that catalyzes the chemical reaction

sn-glycero-3-phosphocholine + H₂O $\rightleftharpoons$ choline + sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are sn-glycero-3-phosphocholine and H₂O, whereas its two products are choline and sn-glycerol 3-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is sn-glycero-3-phosphocholine glycerophosphohydrolase. Other names in common use include glycerophosphinicocholine diesterase, glycerylphosphorylcholinediesterase, sn-glycero-3-phosphorylcholine diesterase, glycerolphosphorylcholine phosphodiesterase, and glycerophosphohydrolase. This enzyme participates in glycerophospholipid metabolism.

[edit] References

IUBMB entry for 3.1.4.2
BRENDA references for 3.1.4.2 (Recommended.)
PubMed references for 3.1.4.2
PubMed Central references for 3.1.4.2
Google Scholar references for 3.1.4.2
Dawson RMC (1956). "Liver glycerylphosphorylcholine diesterase". Biochem. J. 62: 689–693.
HAYAISHI O, KORNBERG A (1954). "Metabolism of phospholipides by bacterial enzymes". J. Biol. Chem. 206: 647–63. PMID 13143024.
Webster GR, Marples EA and Thompson RHS (1957). "Glycerylphosphorylcholine diesterase activity in nervous tissue". Biochem. J. 65: 374–377.