Glycerol dehydratase
From Wikipedia, the free encyclopedia
In enzymology, a glycerol dehydratase (EC 4.2.1.30) is an enzyme that catalyzes the chemical reaction
- glycerol 3-hydroxypropanal + H2O
Hence, this enzyme has one substrate, glycerol, and two products, 3-hydroxypropanal and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is glycerol hydro-lyase (3-hydroxypropanal-forming). Other names in common use include glycerol dehydrase, and glycerol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.
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[edit] Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1IWP and 1MMF.
[edit] References
- IUBMB entry for 4.2.1.30
- BRENDA references for 4.2.1.30 (Recommended.)
- PubMed references for 4.2.1.30
- PubMed Central references for 4.2.1.30
- Google Scholar references for 4.2.1.30
- Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149: 413–9. PMID 7035429.
- Schneider Z, Larsen EG, Jacobson G, Johnson BC, Pawelkiewicz J (1970). "Purification and properties of glycerol dehydrase". J. Biol. Chem. 245: 3388–96. PMID 4989992.
- Schneider Z, Pawelkiewicz J (1966). "The properties of glycerol dehydratase isolated from Aerobacter aerogenes, and the properties of the apoenzyme subunits". Acta. Biochim. Pol. 13: 311–28. PMID 5962440.
- SMILEY KL, SOBOLOV M (1962). "A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus". Arch. Biochem. Biophys. 97: 538–43. doi: . PMID 14039344.
[edit] External links
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- The CAS registry number for this enzyme class is 9077-68-3.