Glycerol-3-phosphate dehydrogenase (NAD+)

From Wikipedia, the free encyclopedia

In enzymology, a glycerol-3-phosphate dehydrogenase (NAD+) (EC 1.1.1.8) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NAD⁺ glycerone phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and NAD⁺, whereas its 3 products are glycerone phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase. Other names in common use include alpha-glycerol phosphate dehydrogenase (NAD+), alpha-glycerophosphate dehydrogenase (NAD+), glycerol 1-phosphate dehydrogenase, glycerol phosphate dehydrogenase (NAD+), glycerophosphate dehydrogenase (NAD+), hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, NAD+-alpha-glycerophosphate dehydrogenase, NAD+-dependent glycerol phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-L-glycerol-3-phosphate dehydrogenase, NAD+-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, and glycerol-3-phosphate dehydrogenase (NAD+). This enzyme participates in glycerophospholipid metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1EVY, 1EVZ, 1JDJ, 1M66, 1M67, 1N1E, 1N1G, 1WPQ, 1X0V, 1X0X, 1YJ8, and 1Z82.

[edit] References

• IUBMB entry for 1.1.1.8
• BRENDA references for 1.1.1.8 (Recommended.)
• PubMed references for 1.1.1.8
• PubMed Central references for 1.1.1.8
• Google Scholar references for 1.1.1.8
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 85-96.
• Brosemer RW, Kuhn RW (1969). "Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases". Biochemistry. 8: 2095–105. doi:10.1021/bi00833a047. PMID 4307630. 
• O'Brien SJ, MacIntyre RJ (1972). "The -glycerophosphate cycle in Drosophila melanogaster. I Biochemical and developmental aspects". Biochem. Genet. 7: 141–61. doi:10.1007/BF00486085. PMID 4340553. 
• Warkentin DL, Fondy TP (1973). "Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme". Eur. J. Biochem. 36: 97–109. doi:10.1111/j.1432-1033.1973.tb02889.x. PMID 4200180. 
• Albertyn J, van Tonder A, Prior BA (1992). "Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae". FEBS. Lett. 308: 130–2. doi:10.1016/0014-5793(92)81259-O. PMID 1499720. 
• Koekemoer TC, Litthauer D, Oelofsen W (1995). "Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase". Int. J. Biochem. Cell. Biol. 27: 625–32. doi:10.1016/1357-2725(95)00012-E. PMID 7671141. 

[edit] External links

The CAS registry number for this enzyme class is 9075-65-4.

• IUBMB entry for 1.1.1.8

• KEGG entry for 1.1.1.8

• BRENDA entry for 1.1.1.8

• NiceZyme view of 1.1.1.8

• EC2PDB: PDB structures for 1.1.1.8

• PRIAM entry for 1.1.1.8

• PUMA2 entry for 1.1.1.8

• IntEnz: Integrated Enzyme entry for 1.1.1.8

• MetaCyc entry for 1.1.1.8

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004367: glycerol-3-phosphate dehydrogenase (NAD+)

• AMIGO entry for GO code 0004367: glycerol-3-phosphate dehydrogenase (NAD+)