Glycerol-3-phosphate dehydrogenase (NAD(P)+)

From Wikipedia, the free encyclopedia

In enzymology, a glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NAD(P)+ $\rightleftharpoons$ glycerone phosphate + NAD(P)H + H⁺

The 3 substrates of this enzyme are sn-glycerol 3-phosphate, NAD⁺, and NADP⁺, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase. Other names in common use include L-glycerol-3-phosphate:NAD(P)+ oxidoreductase, glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide, (phosphate)), glycerol 3-phosphate dehydrogenase (NADP+), and glycerol-3-phosphate dehydrogenase [NAD(P)+]. This enzyme participates in glycerophospholipid metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TXG.

[edit] References

IUBMB entry for 1.1.1.94
BRENDA references for 1.1.1.94 (Recommended.)
PubMed references for 1.1.1.94
PubMed Central references for 1.1.1.94
Google Scholar references for 1.1.1.94
Kito M, Pizer LI (1969). "Purification and regulatory properties of the biosynthetic L-glycerol 3-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 244: 3316–23. PMID 4389388.
Edgar JR, Bell RM (1978). "Biosynthesis in Escherichia coli fo sn-glycerol 3-phosphate, a precursor of phospholipid". J. Biol. Chem. 253: 6348–53. PMID 355254.
Edgar JR, Bell RM (1978). "Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase". J. Biol. Chem. 253: 6354–63. PMID 28326.
Edgar JR, Bell RM (1980). "Biosynthesis in Escherichia coli of sn-glycerol-3-phosphate, a precursor of phospholipid. Further kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase". J. Biol. Chem. 255: 3492–7. PMID 6767719.