Glycerol-3-phosphate cytidylyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a glycerol-3-phosphate cytidylyltransferase (EC 2.7.7.39) is an enzyme that catalyzes the chemical reaction
- CTP + sn-glycerol 3-phosphate
diphosphate + CDP-glycerol
Thus, the two substrates of this enzyme are CTP and sn-glycerol 3-phosphate, whereas its two products are diphosphate and CDP-glycerol.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:sn-glycerol-3-phosphate cytidylyltransferase. Other names in common use include CDP-glycerol pyrophosphorylase, cytidine diphosphoglycerol pyrophosphorylase, cytidine diphosphate glycerol pyrophosphorylase, CTP:glycerol 3-phosphate cytidylyltransferase, and Gro-PCT. This enzyme participates in glycerophospholipid metabolism.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1COZ, 1N1D, and 2B7L.
[edit] References
- IUBMB entry for 2.7.7.39
- BRENDA references for 2.7.7.39 (Recommended.)
- PubMed references for 2.7.7.39
- PubMed Central references for 2.7.7.39
- Google Scholar references for 2.7.7.39
- Shaw DRD (1962). "Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol". Biochem. J. 82: 297–312.
[edit] External links
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- The CAS registry number for this enzyme class is 9027-11-6.
[edit] Gene Ontology (GO) codes
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