Glycerol-3-phosphate 1-dehydrogenase (NADP+)

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In enzymology, a glycerol-3-phosphate 1-dehydrogenase (NADP+) (EC 1.1.1.177) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NADP⁺ $\rightleftharpoons$ D-glyceraldehyde 3-phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and NADP⁺, whereas its 3 products are D-glyceraldehyde 3-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase. Other names in common use include glycerol phosphate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, L-glycerol 3-phosphate:NADP+ oxidoreductase, glycerin-3-phosphate dehydrogenase, NADPH-dependent glycerin-3-phosphate dehydrogenase, and glycerol-3-phosphate 1-dehydrogenase (NADP+).

[edit] References

IUBMB entry for 1.1.1.177
BRENDA references for 1.1.1.177 (Recommended.)
PubMed references for 1.1.1.177
PubMed Central references for 1.1.1.177
Google Scholar references for 1.1.1.177
Glushankov PE, Epifanova VE and Kolotilova AI (1976). "Pentose phosphate pathway of carbohydrate metabolism and NADP-dependent glycerol 3-phosphate dehydrogenase activity in some white rat tissues". Biokhimiya 41: 1788–1790.
Wood T (1974). "Catalysis of pentose phosphate pathway reactions by cytoplasmic fractions from muscle, uterus and liver of the rat, and the presence of a reduced nicotinamide-adenine dinucleotide phosphate-triose phosphate oxidoreductase in rat muscle". Biochem. J. 138: 71–6. PMID 4152128.