Glycerol-1-phosphate dehydrogenase (NAD(P)+)

From Wikipedia, the free encyclopedia

In enzymology, a glycerol-1-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.261) is an enzyme that catalyzes the chemical reaction

sn-glycerol-1-phosphate + NAD(P)+ glycerone phosphate + NAD(P)H + H⁺

The 3 substrates of this enzyme are sn-glycerol-1-phosphate, NAD⁺, and NADP⁺, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase. This enzyme is also called glycerol-1-phosphate dehydrogenase [NAD(P)+].

[edit] References

• IUBMB entry for 1.1.1.261
• BRENDA references for 1.1.1.261 (Recommended.)
• PubMed references for 1.1.1.261
• PubMed Central references for 1.1.1.261
• Google Scholar references for 1.1.1.261
• Koga Y, Kyuragi T, Nishihara M, Sone N (1998). "Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent". J. Mol. Evol. 46: 54–63. doi:10.1007/PL00006283. PMID 9419225. 

[edit] External links

The CAS registry number for this enzyme class is 204594-18-3.

• IUBMB entry for 1.1.1.261

• KEGG entry for 1.1.1.261

• BRENDA entry for 1.1.1.261

• NiceZyme view of 1.1.1.261

• EC2PDB: PDB structures for 1.1.1.261

• PRIAM entry for 1.1.1.261

• PUMA2 entry for 1.1.1.261

• IntEnz: Integrated Enzyme entry for 1.1.1.261

• MetaCyc entry for 1.1.1.261

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050492: glycerol-1-phosphate dehydrogenase [NAD(P)+]

• AMIGO entry for GO code 0050492: glycerol-1-phosphate dehydrogenase [NAD(P)+]