Glyceollin synthase

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In enzymology, a glyceollin synthase (EC 1.14.13.85) is an enzyme that catalyzes the chemical reaction

2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H⁺ + O₂ glyceollin + NADP⁺ + 2 H₂O

The five substrates of this enzyme are 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan, 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan, NADPH, H⁺, and O₂, whereas its three products are glyceollin, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxyge n oxidoreductase (cyclizing). This enzyme participates in isoflavonoid biosynthesis.

[edit] References

• IUBMB entry for 1.14.13.85
• BRENDA references for 1.14.13.85 (Recommended.)
• PubMed references for 1.14.13.85
• PubMed Central references for 1.14.13.85
• Google Scholar references for 1.14.13.85
• Welle R, Grisebach H (1988). "Induction of phytoalexin synthesis in soybean: enzymatic cyclization of prenylated pterocarpans to glyceollin isomers". Arch. Biochem. Biophys. 263: 191–8. doi:10.1016/0003-9861(88)90627-3. PMID 3369863. 

[edit] External links

• IUBMB entry for 1.14.13.85

• KEGG entry for 1.14.13.85

• BRENDA entry for 1.14.13.85

• NiceZyme view of 1.14.13.85

• EC2PDB: PDB structures for 1.14.13.85

• PRIAM entry for 1.14.13.85

• PUMA2 entry for 1.14.13.85

• IntEnz: Integrated Enzyme entry for 1.14.13.85

• MetaCyc entry for 1.14.13.85

• Atomic-resolution structures of enzymes belonging to this class