Glutathionylspermidine amidase

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In enzymology, a glutathionylspermidine amidase (EC 3.5.1.78) is an enzyme that catalyzes the chemical reaction

glutathionylspermidine + H₂O $\rightleftharpoons$ glutathione + spermidine

Thus, the two substrates of this enzyme are glutathionylspermidine and H₂O, whereas its two products are glutathione and spermidine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase. This enzyme is also called glutathionylspermidine amidohydrolase (spermidine-forming). This enzyme participates in glutathione metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2IO7, 2IO8, 2IO9, 2IOA, and 2IOB.

[edit] References

IUBMB entry for 3.5.1.78
BRENDA references for 3.5.1.78 (Recommended.)
PubMed references for 3.5.1.78
PubMed Central references for 3.5.1.78
Google Scholar references for 3.5.1.78
Bollinger JM Jr, Kwon DS, Huisman GW, Kolter R, Walsh CT (1995). "Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase". J. Biol. Chem. 270: 14031–41. PMID 7775463.