Glutathione gamma-glutamylcysteinyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a glutathione gamma-glutamylcysteinyltransferase (EC 2.3.2.15) is an enzyme that catalyzes the chemical reaction

glutathione + [Glu(-Cys)]n-Gly $\rightleftharpoons$ Gly + [Glu(-Cys)]n⁺1-Gly

Thus, the two substrates of this enzyme are glutathione and [[[Glu(-Cys)]n-Gly]], whereas its two products are Gly and [[[Glu(-Cys)]n+1-Gly]].

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase. Other names in common use include phytochelatin synthase, and gamma-glutamylcysteine dipeptidyl transpeptidase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2BTW and 2BU3.

[edit] References

IUBMB entry for 2.3.2.15
BRENDA references for 2.3.2.15 (Recommended.)
PubMed references for 2.3.2.15
PubMed Central references for 2.3.2.15
Google Scholar references for 2.3.2.15
Grill E, Loffler S, Winnacker E-L and Zenk MH (1989). "Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)". Proc. Natl. Acad. Sci. USA 86: 6838–6842. doi:10.1073/pnas.86.18.6838.