Glutathione-homocystine transhydrogenase

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In enzymology, a glutathione---homocystine transhydrogenase (EC 1.8.4.1) is an enzyme that catalyzes the chemical reaction

2 glutathione + homocystine glutathione disulfide + 2 homocysteine

Thus, the two substrates of this enzyme are glutathione and homocystine, whereas its two products are glutathione disulfide and homocysteine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is glutathione:homocystine oxidoreductase. This enzyme participates in methionine metabolism and glutathione metabolism.

[edit] References

• IUBMB entry for 1.8.4.1
• BRENDA references for 1.8.4.1 (Recommended.)
• PubMed references for 1.8.4.1
• PubMed Central references for 1.8.4.1
• Google Scholar references for 1.8.4.1
• Racker E (1955). "Glutathione-homocystine transhydrogenase". J. Biol. Chem. 217: 867–874. 

[edit] External links

The CAS registry number for this enzyme class is 9029-40-7.

• IUBMB entry for 1.8.4.1

• KEGG entry for 1.8.4.1

• BRENDA entry for 1.8.4.1

• NiceZyme view of 1.8.4.1

• EC2PDB: PDB structures for 1.8.4.1

• PRIAM entry for 1.8.4.1

• PUMA2 entry for 1.8.4.1

• IntEnz: Integrated Enzyme entry for 1.8.4.1

• MetaCyc entry for 1.8.4.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047139: glutathione-homocystine transhydrogenase

• AMIGO entry for GO code 0047139: glutathione-homocystine transhydrogenase