Glutarate-semialdehyde dehydrogenase

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In enzymology, a glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) is an enzyme that catalyzes the chemical reaction

glutarate semialdehyde + NAD⁺ + H₂O glutarate + NADH + 2 H⁺

The 3 substrates of this enzyme are glutarate semialdehyde, NAD⁺, and H₂O, whereas its 3 products are glutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glutarate-semialdehyde:NAD+ oxidoreductase. This enzyme is also called glutarate semialdehyde dehydrogenase. This enzyme participates in lysine degradation.

[edit] References

• IUBMB entry for 1.2.1.20
• BRENDA references for 1.2.1.20 (Recommended.)
• PubMed references for 1.2.1.20
• PubMed Central references for 1.2.1.20
• Google Scholar references for 1.2.1.20
• Ichihara A and Ichihara EA (Tokyo). "Metabolism of L-lysine by bacterial enzymes. V. Glutaric semialdehyde dehydrogenase". J. Biochem.: 154–157. 

[edit] External links

The CAS registry number for this enzyme class is 9028-99-3.

• IUBMB entry for 1.2.1.20

• KEGG entry for 1.2.1.20

• BRENDA entry for 1.2.1.20

• NiceZyme view of 1.2.1.20

• EC2PDB: PDB structures for 1.2.1.20

• PRIAM entry for 1.2.1.20

• PUMA2 entry for 1.2.1.20

• IntEnz: Integrated Enzyme entry for 1.2.1.20

• MetaCyc entry for 1.2.1.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047949: glutarate-semialdehyde dehydrogenase

• AMIGO entry for GO code 0047949: glutarate-semialdehyde dehydrogenase