Glutarate-CoA ligase

From Wikipedia, the free encyclopedia

In enzymology, a glutarate-CoA ligase (EC 6.2.1.6) is an enzyme that catalyzes the chemical reaction

ATP + glutarate + CoA ADP + phosphate + glutaryl-CoA

The 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.

[edit] References

• IUBMB entry for 6.2.1.6
• BRENDA references for 6.2.1.6 (Recommended.)
• PubMed references for 6.2.1.6
• PubMed Central references for 6.2.1.6
• Google Scholar references for 6.2.1.6
• Menon GKK, Friedman DL and Stern JR (1960). "Enzymic synthesis of glutaryl-coenzyme A". Biochim. Biophys. Acta 44: 375–377. doi:10.1016/0006-3002(60)91583-3. 

[edit] External links

The CAS registry number for this enzyme class is 9023-68-1.

• IUBMB entry for 6.2.1.6

• KEGG entry for 6.2.1.6

• BRENDA entry for 6.2.1.6

• NiceZyme view of 6.2.1.6

• EC2PDB: PDB structures for 6.2.1.6

• PRIAM entry for 6.2.1.6

• PUMA2 entry for 6.2.1.6

• IntEnz: Integrated Enzyme entry for 6.2.1.6

• MetaCyc entry for 6.2.1.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047948: glutarate-CoA ligase

• AMIGO entry for GO code 0047948: glutarate-CoA ligase