Glutaminyl-peptide cyclotransferase

From Wikipedia, the free encyclopedia

In enzymology, a glutaminyl-peptide cyclotransferase (EC 2.3.2.5) is an enzyme that catalyzes the chemical reaction

L-glutaminyl-peptide $\rightleftharpoons$ 5-oxoprolyl-peptide + NH₃

Hence, this enzyme has one substrate, L-glutaminyl-peptide, and two products, 5-oxoprolyl-peptide and NH₃.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing). Other names in common use include glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, and glutaminyl-transfer ribonucleate cyclotransferase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2AFM, 2AFO, 2AFS, 2AFU, 2AFW, 2AFX, 2AFZ, and 2IWA.

[edit] References

IUBMB entry for 2.3.2.5
BRENDA references for 2.3.2.5 (Recommended.)
PubMed references for 2.3.2.5
PubMed Central references for 2.3.2.5
Google Scholar references for 2.3.2.5
Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS (1987). "An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes". J. Biol. Chem. 262: 8532–6. PMID 3597387.
Fischer WH, Spiess J (1987). "Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides". Proc. Natl. Acad. Sci. U. S. A. 84: 3628–32. doi:10.1073/pnas.84.11.3628. PMID 3473473.
Messer M and Ottesen M (1965). "Isolation and properties of glutamine cyclotransferase of dried papaya latex". C.R. Trav. Lab. Carlsberg 35: 1–24.