Glutamine-fructose-6-phosphate transaminase (isomerizing)
From Wikipedia, the free encyclopedia
In enzymology, a glutamine-fructose-6-phosphate transaminase (isomerizing) (EC 2.6.1.16) is an enzyme that catalyzes the chemical reaction
- L-glutamine + D-fructose 6-phosphate L-glutamate + D-glucosamine 6-phosphate
Thus, the two substrates of this enzyme are L-glutamine and D-fructose 6-phosphate, whereas its two products are L-glutamate and D-glucosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:D-fructose-6-phosphate isomerase (deaminating). Other names in common use include hexosephosphate aminotransferase, glucosamine-6-phosphate isomerase (glutamine-forming), glutamine-fructose-6-phosphate transaminase (isomerizing), D-fructose-6-phosphate amidotransferase, glucosaminephosphate isomerase, glucosamine 6-phosphate synthase, and GlcN6P synthase. This enzyme participates in glutamate metabolism and aminosugars metabolism.
Contents |
[edit] Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1JXA, 1MOQ, 1MOR, 1MOS, 1XFF, 1XFG, 2BPL, 2J6H, 2POC, 2PUT, 2PUV, and 2PUW.
[edit] References
- IUBMB entry for 2.6.1.16
- BRENDA references for 2.6.1.16 (Recommended.)
- PubMed references for 2.6.1.16
- PubMed Central references for 2.6.1.16
- Google Scholar references for 2.6.1.16
- Ghosh S, Blumenthal HJ, Davidson E and Roseman S (1960). "Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate". J. Biol. Chem. 235: 1265–1273.
- GRYDER RM, POGELL BM (1960). "Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes". J. Biol. Chem. 235: 558–62. PMID 13829889.
- LELOIR LF, CARDINI CE (1953). "The biosynthesis of glucosamine". Biochim. Biophys. Acta. 12: 15–22. PMID 13115409.
- Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B (1999). "The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase". Protein. Sci. 8: 596–602. PMID 10091662.
[edit] External links
-
- The CAS registry number for this enzyme class is 9030-45-9.