Glutamate synthase (ferredoxin)

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In enzymology, a glutamate synthase (ferredoxin) (EC 1.4.7.1) is an enzyme that catalyzes the chemical reaction

2 L-glutamate + 2 oxidized ferredoxin $\rightleftharpoons$ L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H⁺

Thus, the two substrates of this enzyme are L-glutamate and oxidized ferredoxin, whereas its 4 products are L-glutamine, 2-oxoglutarate, reduced ferredoxin, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is L-glutamate:ferredoxin oxidoreductase (transaminating). Other names in common use include ferredoxin-dependent glutamate synthase, ferredoxin-glutamate synthase, and glutamate synthase (ferredoxin-dependent). This enzyme participates in nitrogen metabolism. It has 5 cofactors: FAD, Iron, Sulfur, Iron-sulfur, and Flavoprotein.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1LLW, 1LLZ, 1LM1, 1OFD, and 1OFE.

[edit] References

IUBMB entry for 1.4.7.1
BRENDA references for 1.4.7.1 (Recommended.)
PubMed references for 1.4.7.1
PubMed Central references for 1.4.7.1
Google Scholar references for 1.4.7.1
Jang JE, Shaw K, Yu XJ, Petersen D, Pepper K, Lutzko C, Kohn DB (2006). "Specific and stable gene transfer to human embryonic stem cells using pseudotyped lentiviral vectors". Stem. Cells. Dev. 15: 109–17. doi:10.1089/scd.2006.15.109. PMID 16522168.
Lea PJ, Miflin BJ (1974). "Alternative route for nitrogen assimilation in higher plants". Nature. 251: 614–6. doi:10.1038/251614a0. PMID 4423889.