Glutamate synthase (NADH)

From Wikipedia, the free encyclopedia

In enzymology, a glutamate synthase (NADH) (EC 1.4.1.14) is an enzyme that catalyzes the chemical reaction

2 L-glutamate + NAD⁺ L-glutamine + 2-oxoglutarate + NADH + H⁺

Thus, the two substrates of this enzyme are L-glutamate and NAD⁺, whereas its 4 products are L-glutamine, 2-oxoglutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate:NAD+ oxidoreductase (transaminating). Other names in common use include glutamate (reduced nicotinamide adenine dinucleotide) synthase, NADH: GOGAT, L-glutamate synthase (NADH), L-glutamate synthetase, NADH-glutamate synthase, NADH-dependent glutamate synthase, and glutamate synthase (NADH). This enzyme participates in glutamate metabolism and nitrogen metabolism. It employs one cofactor, FMN.

[edit] References

• IUBMB entry for 1.4.1.14
• BRENDA references for 1.4.1.14 (Recommended.)
• PubMed references for 1.4.1.14
• PubMed Central references for 1.4.1.14
• Google Scholar references for 1.4.1.14
• Boland MJ, Benny AG (1977). "Enzymes of nitrogen metabolism in legume nodules. Purification and properties of NADH-dependent glutamate synthase from lupin nodules". Eur. J. Biochem. 79: 355–62. doi:10.1111/j.1432-1033.1977.tb11816.x. PMID 21790. 

[edit] External links

The CAS registry number for this enzyme class is 65589-88-0.

• IUBMB entry for 1.4.1.14

• KEGG entry for 1.4.1.14

• BRENDA entry for 1.4.1.14

• NiceZyme view of 1.4.1.14

• EC2PDB: PDB structures for 1.4.1.14

• PRIAM entry for 1.4.1.14

• PUMA2 entry for 1.4.1.14

• IntEnz: Integrated Enzyme entry for 1.4.1.14

• MetaCyc entry for 1.4.1.14

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016040: glutamate synthase (NADH)

• AMIGO entry for GO code 0016040: glutamate synthase (NADH)