Glutamate-putrescine ligase
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In enzymology, a glutamate-putrescine ligase (EC 6.3.1.11) is an enzyme that catalyzes the chemical reaction
- ATP + L-glutamate + putrescine
ADP + phosphate + gamma-L-glutamylputrescine
The 3 substrates of this enzyme are ATP, L-glutamate, and putrescine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamylputrescine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-glutamate:putrescine ligase (ADP-forming). Other names in common use include gamma-glutamylputrescine synthetase, and YcjK. This enzyme participates in urea cycle and metabolism of amino groups.
[edit] References
- IUBMB entry for 6.3.1.11
- BRENDA references for 6.3.1.11 (Recommended.)
- PubMed references for 6.3.1.11
- PubMed Central references for 6.3.1.11
- Google Scholar references for 6.3.1.11
- Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H (2005). "A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12". J. Biol. Chem. 280: 4602–8. doi:. PMID 15590624.
[edit] External links
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- The CAS registry number for this enzyme class is 914090-78-1.
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