Glutamate-methylamine ligase

From Wikipedia, the free encyclopedia

In enzymology, a glutamate-methylamine ligase (EC 6.3.4.12) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + methylamine ADP + phosphate + N₅-methyl-L-glutamine

The 3 substrates of this enzyme are ATP, L-glutamate, and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is L-glutamate:methylamine ligase (ADP-forming). This enzyme is also called gamma-glutamylmethylamide synthetase.

[edit] References

• IUBMB entry for 6.3.4.12
• BRENDA references for 6.3.4.12 (Recommended.)
• PubMed references for 6.3.4.12
• PubMed Central references for 6.3.4.12
• Google Scholar references for 6.3.4.12
• Kung HF, Wagner C (1969). "Gamma-glutamylmethylamide. A new intermediate in the metabolism of methylamine". J. Biol. Chem. 244: 4136–40. PMID 5800436. 

[edit] External links

The CAS registry number for this enzyme class is 37318-69-7.

• IUBMB entry for 6.3.4.12

• KEGG entry for 6.3.4.12

• BRENDA entry for 6.3.4.12

• NiceZyme view of 6.3.4.12

• EC2PDB: PDB structures for 6.3.4.12

• PRIAM entry for 6.3.4.12

• PUMA2 entry for 6.3.4.12

• IntEnz: Integrated Enzyme entry for 6.3.4.12

• MetaCyc entry for 6.3.4.12

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047943: glutamate-methylamine ligase

• AMIGO entry for GO code 0047943: glutamate-methylamine ligase