Glutamate-1-semialdehyde 2,1-aminomutase
From Wikipedia, the free encyclopedia
In enzymology, a glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) is an enzyme that catalyzes the chemical reaction
- L-glutamate 1-semialdehyde
5-aminolevulinate
Hence, this enzyme has one substrate, L-glutamate 1-semialdehyde, and one product, 5-aminolevulinate.
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (S)-4-amino-5-oxopentanoate 4,5-aminomutase. This enzyme is also called glutamate-1-semialdehyde aminotransferase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, pyridoxal phosphate.
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[edit] Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 2CFB, 2E7U, 2EPJ, 2GSA, 2HOY, 2HOZ, 2HP1, 2HP2, 3GSB, and 4GSA.
[edit] References
- IUBMB entry for 5.4.3.8
- BRENDA references for 5.4.3.8 (Recommended.)
- PubMed references for 5.4.3.8
- PubMed Central references for 5.4.3.8
- Google Scholar references for 5.4.3.8
- Gough SP and Kannangara CG (1978). "Biosynthesis of delta-aminolevulinate in greening barley leaves: glutamate 1-semialdehyde aminotransferase". Carlsberg Res. Commun. 43: 185–194. doi:.
[edit] External links
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- The CAS registry number for this enzyme class is 68518-07-0.
[edit] Gene Ontology (GO) codes
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