Glutaconyl-CoA decarboxylase

From Wikipedia, the free encyclopedia

In enzymology, a glutaconyl-CoA decarboxylase (EC 4.1.1.70) is an enzyme that catalyzes the chemical reaction

4-carboxybut-2-enoyl-CoA $\rightleftharpoons$ but-2-enoyl-CoA + CO₂

Hence, this enzyme has one substrate, 4-carboxybut-2-enoyl-CoA, and two products, but-2-enoyl-CoA and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming). Other names in common use include glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, and 4-carboxybut-2-enoyl-CoA carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1PIX.

[edit] References

IUBMB entry for 4.1.1.70
BRENDA references for 4.1.1.70 (Recommended.)
PubMed references for 4.1.1.70
PubMed Central references for 4.1.1.70
Google Scholar references for 4.1.1.70
Buckel W, Semmler R (1983). "Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria". Eur. J. Biochem. 136: 427–34. doi:10.1111/j.1432-1033.1983.tb07760.x. PMID 6628393.
Buckel W (2001). "Sodium ion-translocating decarboxylases". Biochim. Biophys. Acta. 1505: 15–27. PMID 11248185.