Glucuronolactone reductase

From Wikipedia, the free encyclopedia

In enzymology, a glucuronolactone reductase (EC 1.1.1.20) is an enzyme that catalyzes the chemical reaction

L-gulono-1,4-lactone + NADP⁺ D-glucurono-3,6-lactone + NADPH + H⁺

Thus, the two substrates of this enzyme are L-gulono-1,4-lactone and NADP⁺, whereas its 3 products are D-glucurono-3,6-lactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-gulono-1,4-lactone:NADP+ 1-oxidoreductase. Other names in common use include GRase, and gulonolactone dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

[edit] References

• IUBMB entry for 1.1.1.20
• BRENDA references for 1.1.1.20 (Recommended.)
• PubMed references for 1.1.1.20
• PubMed Central references for 1.1.1.20
• Google Scholar references for 1.1.1.20
• Suzuki K, Mano Y and Shimazono N (Tokyo). "Conversion of L-gulonolactone to L-ascorbic acid; properties of the microsomal enzyme in rat liver". J. Biochem.: 313–315. 

[edit] External links

The CAS registry number for this enzyme class is 9028-30-2.

• IUBMB entry for 1.1.1.20

• KEGG entry for 1.1.1.20

• BRENDA entry for 1.1.1.20

• NiceZyme view of 1.1.1.20

• EC2PDB: PDB structures for 1.1.1.20

• PRIAM entry for 1.1.1.20

• PUMA2 entry for 1.1.1.20

• IntEnz: Integrated Enzyme entry for 1.1.1.20

• MetaCyc entry for 1.1.1.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047941: glucuronolactone reductase

• AMIGO entry for GO code 0047941: glucuronolactone reductase