Glucuronate isomerase

From Wikipedia, the free encyclopedia

In enzymology, a glucuronate isomerase (EC 5.3.1.12) is an enzyme that catalyzes the chemical reaction

D-glucuronate $\rightleftharpoons$ D-fructuronate

Hence, this enzyme has one substrate, D-glucuronate, and one product, D-fructuronate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-glucuronate aldose-ketose-isomerase. Other names in common use include uronic isomerase, uronate isomerase, D-glucuronate isomerase, uronic acid isomerase, and D-glucuronate ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1J5S and 2Q01.

[edit] References

IUBMB entry for 5.3.1.12
BRENDA references for 5.3.1.12 (Recommended.)
PubMed references for 5.3.1.12
PubMed Central references for 5.3.1.12
Google Scholar references for 5.3.1.12
Ashwell G, Wahba AJ and Hickman J (1960). "Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli". J. Biol. Chem. 235: 1559–1565.
KILGORE WW, STARR MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora". J. Biol. Chem. 234: 2227–35. PMID 14409051.