Glucuronate-2-sulfatase

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In enzymology, a glucuronate-2-sulfatase (EC 3.1.6.18) is an enzyme that catalyzes the chemical reaction of cleaving off the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase. This enzyme is also called glucurono-2-sulfatase. This enzyme participates in glycosaminoglycan degradation and glycan structures - degradation.

[edit] References

• IUBMB entry for 3.1.6.18
• BRENDA references for 3.1.6.18 (Recommended.)
• PubMed references for 3.1.6.18
• PubMed Central references for 3.1.6.18
• Google Scholar references for 3.1.6.18
• Shaklee PN, Glaser JH, Conrad HE (1985). "A sulfatase specific for glucuronic acid 2-sulfate residues in glycosaminoglycans". J. Biol. Chem. 260: 9146–9. PMID 4019466. 

[edit] External links

The CAS registry number for this enzyme class is 98597-45-6.

• IUBMB entry for 3.1.6.18

• KEGG entry for 3.1.6.18

• BRENDA entry for 3.1.6.18

• NiceZyme view of 3.1.6.18

• EC2PDB: PDB structures for 3.1.6.18

• PRIAM entry for 3.1.6.18

• PUMA2 entry for 3.1.6.18

• IntEnz: Integrated Enzyme entry for 3.1.6.18

• MetaCyc entry for 3.1.6.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0015024: glucuronate-2-sulfatase

• AMIGO entry for GO code 0015024: glucuronate-2-sulfatase