Glucose 1-dehydrogenase (NAD+)

From Wikipedia, the free encyclopedia

In enzymology, a glucose 1-dehydrogenase (NAD+) (EC 1.1.1.118) is an enzyme that catalyzes the chemical reaction

D-glucose + NAD⁺ D-glucono-1,5-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are D-glucose and NAD⁺, whereas its 3 products are D-glucono-1,5-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glucose:NAD+ 1-oxidoreductase. Other names in common use include D-glucose:NAD+ oxidoreductase, D-aldohexose dehydrogenase, and glucose 1-dehydrogenase (NAD+).

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DTD, 2DTE, and 2DTX.

[edit] References

• IUBMB entry for 1.1.1.118
• BRENDA references for 1.1.1.118 (Recommended.)
• PubMed references for 1.1.1.118
• PubMed Central references for 1.1.1.118
• Google Scholar references for 1.1.1.118
• Hu, ASL and Cline AL (1964). "The regulation of some sugar dehydrogenases in a pseudomonad". Biochim. Biophys. Acta 93: 237–245. 

[edit] External links

The CAS registry number for this enzyme class is 37250-49-0.

• IUBMB entry for 1.1.1.118

• KEGG entry for 1.1.1.118

• BRENDA entry for 1.1.1.118

• NiceZyme view of 1.1.1.118

• EC2PDB: PDB structures for 1.1.1.118

• PRIAM entry for 1.1.1.118

• PUMA2 entry for 1.1.1.118

• IntEnz: Integrated Enzyme entry for 1.1.1.118

• MetaCyc entry for 1.1.1.118

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047934: glucose 1-dehydrogenase (NAD+)

• AMIGO entry for GO code 0047934: glucose 1-dehydrogenase (NAD+)