Glucose 1-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a glucose 1-dehydrogenase (EC 1.1.1.47) is an enzyme that catalyzes the chemical reaction

beta-D-glucose + NAD(P)+ $\rightleftharpoons$ D-glucono-1,5-lactone + NAD(P)H + H⁺

The 3 substrates of this enzyme are beta-D-glucose, NAD⁺, and NADP⁺, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Other names in common use include D-glucose dehydrogenase (NAD(P)+), and hexose phosphate dehydrogenase. This enzyme participates in pentose phosphate pathway.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1G6K, 1GCO, 1GEE, 1RWB, 1SPX, 2B5V, 2B5W, 2CD9, and 2CDA.

[edit] References

IUBMB entry for 1.1.1.47
BRENDA references for 1.1.1.47 (Recommended.)
PubMed references for 1.1.1.47
PubMed Central references for 1.1.1.47
Google Scholar references for 1.1.1.47
K, Rick W, Staudinger HJ (1975). "[A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)]". Z. Klin. Chem. Klin. Biochem. 13: 101–7. PMID 810982.
Brink NG (1953). "Beef liver glucose dehydrogenase. 1. Purification and properties". Acta Chem. Scand. 7: 1081–1089.
Pauly HE and Pfleiderer G (1976). "D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure". Hoppe-Seyler's Z. Physiol. Chem. 356: 1613–1623.
STRECKER HJ, KORKES S (1952). "Glucose dehydrogenase". J. Biol. Chem. 196: 769–84. PMID 12981017.
Thompson RE, Carper WR (1970). "Glucose dehydrogenase from pig liver. I. Isolation and purification". Biochim. Biophys. Acta. 198: 397–406. PMID 4392298.