Glucose-6-phosphate isomerase

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Glucose phosphate isomerase
Enzyme Glucose-6-phosphate isomerase PDB Code PDB 1GZV Organism Pig Tissue Muscle Complexed molecules 5-phosphoarabinoate
Symbol(s):	GPI
Genetic data
Locus:	Chr. 19 q13.1
Database Links
EC number:	5.3.1.9
Entrez:	2821
OMIM:	172400
RefSeq:	NM_000175
UniProt:	P06744

Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose-6-phosphate in the second step of glycolysis. An unrelated enzyme, D-xylose isomerase (EC 5.3.1.5) catalyzes the isomerization of glucose to fructose, and is sometimes called "glucose isomerase".

The human variant of this enzyme is encoded by the GPI gene.

[edit] In glycolysis

α-D-Glucose 6-phosphate	Phosphoglucose isomerase		β-D-Fructose 6-phosphate
	Phosphoglucose isomerase

Compound C00668 at KEGG Pathway Database. Enzyme 5.3.1.9 at KEGG Pathway Database. Compound C05345 at KEGG Pathway Database. Reaction R00771 at KEGG Pathway Database.

[edit] As a glucose isomerase

D-Glucose	Phosphoglucose isomerase		D-Fructose
			Image:D-fructose wpmp.png
	Phosphoglucose isomerase

[edit] Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.

v • d • e Metabolism: carbohydrate metabolism: glycolysis/gluconeogenesis enzymes Glycolysis Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase Aldolase - Triosephosphate isomerase Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase Gluconeogenesis only to oxaloacetate: Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase from lactate (Cori cycle): Lactate dehydrogenase from alanine (Alanine cycle): Alanine transaminase from glycerol: Glycerol kinase - Glycerol dehydrogenase Regulatory Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase see also disorders

v • d • e Metabolism: carbohydrate metabolism: glycolysis/gluconeogenesis enzymes Glycolysis Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase Aldolase - Triosephosphate isomerase Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase Gluconeogenesis only to oxaloacetate: Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase from lactate (Cori cycle): Lactate dehydrogenase from alanine (Alanine cycle): Alanine transaminase from glycerol: Glycerol kinase - Glycerol dehydrogenase Regulatory Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase see also disorders

v • d • e Intramolecular oxidoreductases isomerases (EC 5.3) 5.3.1 - Aldoses/Ketoses Triosephosphate isomerase - Phosphopentose isomerase - Mannose phosphate isomerase - Glucose isomerase 5.3.3 - C=C Isopentenyl-diphosphate delta isomerase - Enoyl CoA isomerase 5.3.4 - S-S Protein disulfide isomerase (PDIA3) 5.3.99 - other Prostaglandin D2 synthase - Prostaglandin E synthase - Prostacyclin synthase - Thromboxane-A synthase