Glucose-1-phosphate thymidylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) is an enzyme that catalyzes the chemical reaction

dTTP + alpha-D-glucose 1-phosphate $\rightleftharpoons$ diphosphate + dTDP-glucose

Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and dTDP-glucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include glucose 1-phosphate thymidylyltransferase, dTDP-glucose synthase, dTDP-glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, and TDP-glucose pyrophosphorylase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FXO, 1FZW, 1G0R, 1G1L, 1G23, 1G2V, 1G3L, 1H5R, 1H5S, 1H5T, 1IIM, 1IIN, 1LVW, 1MC3, 1MP3, 1MP4, 1MP5, 2GGO, and 2GGQ.

[edit] References

IUBMB entry for 2.7.7.24
BRENDA references for 2.7.7.24 (Recommended.)
PubMed references for 2.7.7.24
PubMed Central references for 2.7.7.24
Google Scholar references for 2.7.7.24
Kornfeld S and Glaser L (1961). "The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose". J. Biol. Chem. 236: 1791–1794.
Pazur JH and Shuey EW (1961). "The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose". J. Biol. Chem. 236: 1780–1785.