Gluconolactonase

From Wikipedia, the free encyclopedia

In enzymology, a gluconolactonase (EC 3.1.1.17) is an enzyme that catalyzes the chemical reaction

D-glucono-1,5-lactone + H₂O D-gluconate

Thus, the two substrates of this enzyme are D-glucono-1,5-lactone and H₂O, whereas its product is D-gluconate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is D-glucono-1,5-lactone lactonohydrolase. Other names in common use include lactonase, aldonolactonase, glucono-delta-lactonase, and gulonolactonase. This enzyme participates in 3 metabolic pathways: pentose phosphate pathway, ascorbate and aldarate metabolism, and caprolactam degradation.

[edit] References

• IUBMB entry for 3.1.1.17
• BRENDA references for 3.1.1.17 (Recommended.)
• PubMed references for 3.1.1.17
• PubMed Central references for 3.1.1.17
• Google Scholar references for 3.1.1.17
• BRODIE AF, LIPMANN F (1955). "Identification of a gluconolactonase". J. Biol. Chem. 212: 677–85. PMID 14353869. 
• Bublitz C and Lehninger AL (1961). "The role of aldonolactonase in the conversion of L-gulonate to L-ascorbate". Biochim. Biophys. Acta 47: 288–297. doi:10.1016/0006-3002(61)90289-X. 
• Suzuki K, Kawada M and Shimazono N (Tokyo). "Soluble lactonase. Identity of lactonase I and aldonolactonase with gluconolactonase". J. Biochem.: 448–449. 

[edit] External links

The CAS registry number for this enzyme class is 9012-73-1.

• IUBMB entry for 3.1.1.17

• KEGG entry for 3.1.1.17

• BRENDA entry for 3.1.1.17

• NiceZyme view of 3.1.1.17

• EC2PDB: PDB structures for 3.1.1.17

• PRIAM entry for 3.1.1.17

• PUMA2 entry for 3.1.1.17

• IntEnz: Integrated Enzyme entry for 3.1.1.17

• MetaCyc entry for 3.1.1.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004341: gluconolactonase

• AMIGO entry for GO code 0004341: gluconolactonase