Gluconate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a gluconate dehydratase (EC 4.2.1.39) is an enzyme that catalyzes the chemical reaction

D-gluconate 2-dehydro-3-deoxy-D-gluconate + H₂O

Hence, this enzyme has one substrate, D-gluconate, and two products, 2-dehydro-3-deoxy-D-gluconate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.

[edit] References

• IUBMB entry for 4.2.1.39
• BRENDA references for 4.2.1.39 (Recommended.)
• PubMed references for 4.2.1.39
• PubMed Central references for 4.2.1.39
• Google Scholar references for 4.2.1.39
• Andreesen JR, Gottschalk G (1969). "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69: 160–70. doi:10.1007/BF00409760. PMID 5383859. 

[edit] External links

The CAS registry number for this enzyme class is 37290-75-8.

• IUBMB entry for 4.2.1.39

• KEGG entry for 4.2.1.39

• BRENDA entry for 4.2.1.39

• NiceZyme view of 4.2.1.39

• EC2PDB: PDB structures for 4.2.1.39

• PRIAM entry for 4.2.1.39

• PUMA2 entry for 4.2.1.39

• IntEnz: Integrated Enzyme entry for 4.2.1.39

• MetaCyc entry for 4.2.1.39

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047929: gluconate dehydratase

• AMIGO entry for GO code 0047929: gluconate dehydratase