Gluconate 5-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a gluconate 5-dehydrogenase (EC 1.1.1.69) is an enzyme that catalyzes the chemical reaction

D-gluconate + NAD(P)+ $\rightleftharpoons$ 5-dehydro-D-gluconate + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-gluconate, NAD⁺, and NADP⁺, whereas its 4 products are 5-dehydro-D-gluconate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NAD(P)+ 5-oxidoreductase. Other names in common use include 5-keto-D-gluconate 5-reductase, 5-keto-D-gluconate 5-reductase, 5-ketogluconate 5-reductase, 5-ketogluconate reductase, and 5-keto-D-gluconate reductase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VL8.

[edit] References

IUBMB entry for 1.1.1.69
BRENDA references for 1.1.1.69 (Recommended.)
PubMed references for 1.1.1.69
PubMed Central references for 1.1.1.69
Google Scholar references for 1.1.1.69
Ameyama M and Adachi O (1982). "5-Keto-D-gluconate reductase from Gluconobacter suboxydans". Methods Enzymol. 89: 198–202.
Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6: 2726–32. doi:10.1002/pmic.200500419. PMID 16526094.
Okamoto K (Tokyo). "Enzymic studies on the formation of 5-ketogluconic acid by Acetobacter suboxydans. II. 5-Ketogluconate reductase". J. Biochem.: 448.