Glucagon-like peptide 2 receptor

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Glucagon-like peptide 2 receptor
Identifiers
Symbol(s) GLP2R;
External IDs OMIM: 603659 MGI: 2136733 HomoloGene: 3132
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9340 93896
Ensembl ENSG00000065325 n/a
Uniprot O95838 n/a
Refseq NM_004246 (mRNA)
NP_004237 (protein)		 XM_991784 (mRNA)
XP_996878 (protein)
Location Chr 17: 9.67 - 9.73 Mb n/a
Pubmed search [1] [2]

The gene for the glucagon-like peptide 2 receptor (GLP-2) is on chromosome 17.[1]

Contents

[edit] See also

[edit] References

  1. ^ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" ([dead link] – Scholar search). Recept. Channels 8 (3-4): 179–88. PMID 12529935. 

[edit] Further reading

  • Burrin DG, Petersen Y, Stoll B, Sangild P (2001). "Glucagon-like peptide 2: a nutrient-responsive gut growth factor.". J. Nutr. 131 (3): 709–12. PMID 11238747. 
  • Munroe DG, Gupta AK, Kooshesh F, et al. (1999). "Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1569–73. PMID 9990065. 
  • Yusta B, Huang L, Munroe D, et al. (2000). "Enteroendocrine localization of GLP-2 receptor expression in humans and rodents.". Gastroenterology 119 (3): 744–55. PMID 10982769. 
  • Thulesen J, Knudsen LB, Hartmann B, et al. (2002). "The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.". Regul. Pept. 103 (1): 9–15. PMID 11738243. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Koehler JA, Yusta B, Drucker DJ (2005). "The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.". Mol. Endocrinol. 19 (2): 459–73. doi:10.1210/me.2004-0196. PMID 15471943. 
  • Ørskov C, Hartmann B, Poulsen SS, et al. (2005). "GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.". Regul. Pept. 124 (1-3): 105–12. doi:10.1016/j.regpep.2004.07.009. PMID 15544847. 
  • Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. 
  • Estall JL, Koehler JA, Yusta B, Drucker DJ (2005). "The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.". J. Biol. Chem. 280 (23): 22124–34. doi:10.1074/jbc.M500078200. PMID 15817468. 
  • Guan X, Karpen HE, Stephens J, et al. (2006). "GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.". Gastroenterology 130 (1): 150–64. doi:10.1053/j.gastro.2005.11.005. PMID 16401478. 
  • Sams A, Hastrup S, Andersen M, Thim L (2006). "Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines.". Eur. J. Pharmacol. 532 (1-2): 18–23. doi:10.1016/j.ejphar.2005.12.001. PMID 16448646. 

[edit] External links

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened