GLRB

From Wikipedia, the free encyclopedia


Glycine receptor, beta
PDB rendering based on 1t3e.
Available structures: 1t3e
Identifiers
Symbol(s) GLRB;
External IDs OMIM: 138492 MGI: 95751 HomoloGene: 20224
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2743 14658
Ensembl ENSG00000109738 ENSMUSG00000028020
Uniprot P48167 O54848
Refseq NM_000824 (mRNA)
NP_000815 (protein)		 NM_010298 (mRNA)
NP_034428 (protein)
Location Chr 4: 158.22 - 158.31 Mb Chr 3: 80.93 - 81 Mb
Pubmed search [1] [2]

Glycine receptor, beta, also known as GLRB, is a human gene.[1]

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: GLRB glycine receptor, beta.

[edit] Further reading

  • Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit.". Neuron 15 (3): 563–72. PMID 7546736. 
  • Handford CA, Lynch JW, Baker E, et al. (1996). "The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.". Brain Res. Mol. Brain Res. 35 (1-2): 211–9. PMID 8717357. 
  • Milani N, Mülhardt C, Weber RG, et al. (1998). "The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism.". Genomics 50 (3): 341–5. doi:10.1006/geno.1998.5324. PMID 9676428. 
  • Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys.". Nephron 82 (3): 254–60. PMID 10395998. 
  • Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB).". Hum. Mol. Genet. 11 (7): 853–60. PMID 11929858. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors.". J. Biol. Chem. 279 (2): 876–83. doi:10.1074/jbc.M307684200. PMID 14563849. 
  • Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation.". Recept. Channels 9 (6): 353–61. PMID 14698963. 
  • Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.". J. Neurosci. 24 (25): 5816–26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors.". Neuron 45 (5): 727–39. doi:10.1016/j.neuron.2005.01.028. PMID 15748848. 

[edit] External links

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